Ingrid Fleming Selected Research

Hypertension (High Blood Pressure)

10/2023	Perivascular adipose tissue as a source of therapeutic targets and clinical biomarkers.
1/2022	Loss of Endothelial Cytochrome P450 Reductase Induces Vascular Dysfunction in Mice.
1/2020	Role of cytochrome P450-derived, polyunsaturated fatty acid mediators in diabetes and the metabolic syndrome.
1/2019	Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure.
10/2011	Cytochrome P450-dependent eicosanoid production and crosstalk.
10/2009	Inhibition of the soluble epoxide hydrolase by tyrosine nitration.
4/2005	Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension.
1/2005	Cytochrome P-450 under pressure: more evidence for a link between 20-hydroxyeicosatetraenoic acid and hypertension.
3/2003	20-HETE-induced contraction of small coronary arteries depends on the activation of Rho-kinase.

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Ingrid Fleming Research Topics

Disease

23	Inflammation (Inflammations) 01/2024 - 09/2007
18	Hypoxia (Hypoxemia) 10/2023 - 11/2002
14	Cardiovascular Diseases (Cardiovascular Disease) 10/2023 - 04/2005
13	Neoplasms (Cancer) 01/2023 - 07/2011
11	Atherosclerosis 10/2023 - 11/2004
9	Hypertension (High Blood Pressure) 10/2023 - 03/2003
7	Vascular Diseases (Vascular Disease) 01/2021 - 01/2008
6	Neoplasm Metastasis (Metastasis) 01/2022 - 01/2013
6	Type 2 Diabetes Mellitus (MODY) 01/2021 - 01/2008
5	Insulin Resistance 12/2023 - 01/2006
5	Thrombosis (Thrombus) 01/2023 - 06/2007
5	Breast Neoplasms (Breast Cancer) 01/2022 - 01/2013
5	Myocardial Infarction 01/2021 - 02/2011
4	Coronary Artery Disease (Coronary Atherosclerosis) 12/2018 - 02/2003
4	Myocardial Ischemia (Ischemic Heart Diseases) 01/2018 - 02/2003
4	Diabetes Mellitus 07/2015 - 09/2008
4	Vascular Remodeling 03/2011 - 04/2006
4	Pulmonary Hypertension 02/2011 - 04/2006
3	Obesity 01/2022 - 07/2012
3	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2020 - 12/2017
3	Atherosclerotic Plaque (Atheroma) 06/2019 - 01/2013
3	Infarction (Infarctions) 01/2019 - 02/2011
2	Virus Diseases (Viral Diseases) 10/2023 - 01/2021
2	Heart Failure 10/2023 - 08/2007
2	Reperfusion Injury 10/2023 - 01/2018
2	Alzheimer Disease (Alzheimer's Disease) 01/2023 - 05/2015
2	Ischemia 01/2023 - 01/2012
2	Malignant Hyperthermia 01/2022 - 01/2020
2	Carcinoma (Carcinomatosis) 01/2022 - 01/2019
2	Body Weight (Weight, Body) 01/2022 - 09/2008
2	Polycystic Kidney Diseases (Polycystic Kidney Disease) 10/2021 - 01/2020
2	Carcinogenesis 07/2021 - 01/2021
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2020 - 10/2014
2	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 01/2019 - 08/2015
2	Disease Progression 01/2019 - 01/2018
2	Pathologic Neovascularization 01/2018 - 12/2011
2	Glioma (Gliomas) 09/2017 - 01/2016
2	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 08/2013 - 12/2005
2	Wounds and Injuries (Trauma) 06/2013 - 12/2011

Drug/Important Bio-Agent (IBA)

17	Proteins (Proteins, Gene)FDA Link 07/2021 - 12/2005
16	Epoxide HydrolasesIBA 07/2021 - 04/2005
15	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 07/2021 - 01/2004
14	EnzymesIBA 01/2022 - 01/2004
11	AcidsIBA 10/2023 - 01/2004
7	Epoxy Compounds (Epoxides)IBA 10/2023 - 10/2011
7	Fatty Acids (Saturated Fatty Acids)IBA 10/2023 - 07/2009
7	LipidsIBA 01/2022 - 01/2008
7	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2019 - 01/2004
6	CalpainIBA 12/2020 - 05/2009
5	Glucose (Dextrose)FDA LinkGeneric 12/2023 - 01/2013
5	11,12-epoxy-5,8,14-eicosatrienoic acidIBA 01/2023 - 12/2005
5	Retinaldehyde (Retinal)IBA 10/2021 - 03/2008
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 04/2024 - 02/2003
4	Biomarkers (Surrogate Marker)IBA 10/2023 - 01/2016
4	CytokinesIBA 01/2023 - 12/2011
4	Transcription Factors (Transcription Factor)IBA 01/2023 - 12/2011
4	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2023 - 09/2008
4	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2022 - 12/2019
4	ProstaglandinsIBA 01/2022 - 07/2011
4	Messenger RNA (mRNA)IBA 02/2021 - 12/2005
4	Arachidonic Acid (Vitamin F)IBA 01/2021 - 01/2007
4	CytochromesIBA 01/2020 - 02/2011
4	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 01/2019 - 04/2005
4	Angiotensin IIIBA 07/2013 - 11/2004
3	EicosanoidsIBA 10/2023 - 01/2018
3	Oxygen (Dioxygen)IBA 01/2023 - 01/2004
3	Insulin (Novolin)FDA Link 01/2022 - 04/2009
3	IntegrinsIBA 01/2021 - 09/2010
3	Docosahexaenoic AcidsIBA 01/2020 - 01/2019
3	CystathionineIBA 01/2020 - 01/2019
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2019 - 12/2011
3	MicroRNAs (MicroRNA)IBA 01/2018 - 07/2015
3	20-hydroxy-5,8,11,14-eicosatetraenoic acidIBA 01/2016 - 03/2003
3	Nitric Oxide Synthase (NO Synthase)IBA 01/2012 - 01/2008
3	Sulfaphenazole FDA Link 03/2008 - 01/2004
2	LeukotrienesIBA 01/2024 - 01/2021
2	Hormones (Hormone)IBA 12/2023 - 07/2009
2	Long Noncoding RNAIBA 01/2023 - 01/2019
2	Pyruvic Acid (Pyruvate)IBA 01/2022 - 01/2019
2	Cysteine (L-Cysteine)FDA Link 01/2022 - 01/2012
2	Dinoprostone (PGE2)FDA Link 01/2022 - 01/2020
2	Naproxen (Naprosyn)FDA LinkGeneric 01/2022 - 06/2007
2	Prostaglandin-E SynthasesIBA 01/2022 - 07/2011
2	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 01/2022 - 01/2020
2	ZymosanIBA 02/2021 - 10/2011
2	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 01/2021 - 01/2012
2	RNA (Ribonucleic Acid)IBA 01/2021 - 10/2019
2	LyasesIBA 01/2020 - 01/2019
2	Tyrosine (L-Tyrosine)FDA Link 12/2019 - 01/2008
2	19,20-dihydroxydocosapentaenoic acidIBA 12/2019 - 01/2019
2	Acetyl-CoA CarboxylaseIBA 01/2019 - 04/2013
2	ApolipoproteinsIBA 01/2019 - 11/2004
2	Adenosine Triphosphate (ATP)IBA 12/2018 - 07/2009
2	Sphingosine-1-Phosphate ReceptorsIBA 09/2017 - 05/2009
2	ProteomeIBA 01/2017 - 07/2012
2	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA 09/2014 - 06/2014
2	LipopolysaccharidesIBA 06/2014 - 07/2013

Therapy/Procedure

6	Therapeutics 01/2020 - 01/2008
2	Precision Medicine 10/2023 - 11/2016
2	Ligation 01/2019 - 05/2010